κ light-chain deficiency

κ light-chain deficiency is produced by mutations in IGKC located on chromosome 2p11. The transmittance is autosomal recessive and have been point mutations described in one family. Pathogenesis include failure to express kappa chains but the reason is not known.

Alternative names

Kappa-chain deficiency

Classification

  • Deficiencies predominantly affecting antibody production
    • Light-chain deficiency

Inheritance

Autosomal recessive

OMIM

+147200 Immunoglobulin kappa constant region; IGKC

Cross references

Incidence

Incidence is not known.