Transient hypogammaglobulinemia of infancy

Transient hypogammaglobulinemia of infancy (THI) results from a delay in the maturation of immunoglobulin production.This disorder, affecting both males and females, presents at 5-6 months of age and can last as long as 3 years. The infant does not synthesize IgG, although the levels of IgM (e.g. the natural isohemagglutinins) and IgA are normal.

Alternative names

THI

Transient hypogammaglobulinemia of infancy (THI)

Classification

  • Deficiencies predominantly affecting antibody production
    • Other antibody deficiencies

Inheritance

Unknown

OMIM

%240500 Common variable immunodeficiency

Cross references

Phenotypically related immunodeficiencies

IDR factfile for common variable immunodeficiency

Incidence

It is not known.