Printable factfile
Gene Information
Names
HUGO name: WAS
Alias(es):
- IMD2
- THC
- WASP
- Wiskott-Aldrich syndrome protein
Localization
Reference sequences
- DNA: AF196970 (EMBL)
- cDNA: U12707 (EMBL)
- Protein: P42768 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Possible regulator of lymphocyte and platelet function. May be involved in signaling pathways with cytoskeletal function.
Subunit:
Binds to Cdc42, Rac, Nck, Fyn, Src kinase Fgr, BTK, Abl, Wip, and to the P85 subunit of Plc-gamma.
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| leukocyte | 21.73 | 8:8982 |
| T cells from T cell leukemia | 10.18 | 1:2397 |
| thymus, pooled | 7.70 | 1:3169 |
| lymph | 7.58 | 20:64395 |
| B-cells | 7.38 | 5:16533 |
| spleen | 6.75 | 2:7229 |
| placenta human 8 week | 6.05 | 1:4035 |
| lymph, T-cell | 5.74 | 2:8503 |
| colon, 2 pooled adenocarcinomas | 5.53 | 2:8815 |
| leukopheresis | 5.35 | 1:4557 |