ImmunoDeficiency Resource (IDR)

Names

HUGO name: TYK2

HUGO name: STAT3

Localization

Reference sequences

Reference sequences

Chromosomal location

Chromosomal location

Maps

Maps

Variations / Mutations

• TYK2base; Mutation registry for Tyk2 deficiency

• STAT3base; Mutation registry for STAT3 deficiency

Other gene-based resources

Description

Protein function:

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain

Catalytic activity:

ATP + a [protein]-l-tyrosine = ADP + a [protein]-l-tyrosine phosphate

Tissue specificity:

Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines

Similarity:

Belongs to the protein kinase superfamily. Tyr protein kinase family. Jak subfamily

Protein function:

Transcription factor that binds to the interleukin-6 (il-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by il31 through il31ra

Subunit:

Forms a homodimer or a heterodimer with a related family member (at least stat1). Interacts with ncoa1, pelp1, socs7 and statip1. Interacts with hcv core protein. Interacts with il23r in presence of il23. Interacts with il31ra

Subcellular location:

Cytoplasm. Nucleus. Note=translocated into the nucleus in response to phosphorylation

Post-translational modification:

Tyrosine phosphorylated in response to il-6, il-11, cntf, lif, csf-1, egf, pdgf, ifn-alpha and osm. Phosphorylated on serine upon dna damage, probably by atm or atr. Serine phosphorylation is important for the formation of stable dna-binding stat3 homodimers and maximal transcriptional activity

Alternative products:

Event=alternative splicing; named isoforms=2; name=1; isoid=p40763-1; sequence=displayed; name=del-701; isoid=p40763-2; sequence=vsp_010474;

Miscellaneous:

Involved in the gp130-mediated signaling pathway

Tissue specificity:

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

Similarity:

Belongs to the transcription factor stat family

Structures (PDB)

Domains

FERM domain: 26-431

SH2; atypical domain: 450-529

Protein kinase 1 domain: 589-875

Protein kinase 2 domain: 897-1176

SH2 domain: 580-670

Other features

Non-receptor tyrosine-protein kinase tyk2: 1-1187

ATP nucleotide phosphate-binding region: 903-911

Atp binding site: 930

Signal transducer and activator of transcription 3: 1-770

Other related resourses:

Other related resourses:

Expression pattern for human

Animal models

Mouse

Mouse