Printable factfile
Gene Information
Names
HUGO name: MYO5A
Alias(es):
- MYH12
- myosin VA
- heavy polypeptide 12
- Myosin 5A
- Dilute myosin heavy chain, non-muscle
- Myosin heavy chain 12
- Myoxin
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. May be involved in melanosome transport, or alternatively, it may be required for some polarization process involved in dendrite formation.
Subunit:
May be a homodimer, which associates with multiple calmodulin or myosin light chains.
Alternative products:
3 isoforms are produced by alternative splicing.
Other features
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| eye, ciliary body | 57.52 | 1:199 |
| melanoma (mewo cell line) | 14.32 | 2:1599 |
| foreskin, melanocyte | 6.79 | 8:13478 |
| human skeletal muscle | 4.26 | 4:10746 |
| pool, melanocyte+heart+uterus | 2.08 | 6:32944 |
| human fetal eye | 2.07 | 1:5520 |
| human lung epithelial cell lines untreated lps 6hr to lps | 1.82 | 1:6278 |
| normal lung epithelial cells tissue nos 369-371 and 380-383 | 1.71 | 1:6713 |
| breast | 1.36 | 5:42231 |
| rpe and choroid | 1.08 | 1:10565 |