Myeloperoxidase deficiency

Most patients with myeloperoxidase deficiency are asymptomatic and the condition is usually undiagnosed. Patients have recurrent infections, particularly candidal and an increased incidence of malignancy. Visceral infections with Candida are most of the time associated with diabetus mellitus. Patients can present also an increased number of blood eosinophils.

Therapeutic options

  • Maintenance antibiotic therapy is not recommended if myeloperoxidase deficient subjects do not suffer from infections. Patients affected also by diabetus mellitus, with a high tendency to localized and systemic infections need a prompt and prolonged therapy with antibiotics. In case of infections with resistant micro-organisms or species of fungi, parenteral antibiotics are beneficial.
  • Myeloperoxidase deficiency, eMedicine

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