Printable factfile
Gene Information
Names
HUGO name: G6PC
Alias(es):
- G6PT
- GSD1a
- SLC37A4
- glucose-6-phosphatase, catalytic
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
May be a single membrane channel protein acting both as a hydrolase and a translocase. It is the key enzyme in homeostatic regulation of blood glucose levels.
Catalytic activity:
D-glucose 6-phosphate + h(2)o = d-glucose + phosphate
Subcellular location:
Integral membrane protein. Endoplasmic reticulum.
Pathway:
Gluconeogenesis and glycogenolysis; last step.
Other features
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| muscle, striated | 24.40 | 1:3462 |
| hepatocellular carcinoma | 23.63 | 4:14298 |
| liver | 22.99 | 10:36737 |
| lung metatastic chondrosarcoma | 13.08 | 1:6458 |
| corresponding non cancerous liver tissue | 6.05 | 1:13955 |
| kidney | 5.74 | 8:117781 |
| pool, liver+spleen | 4.12 | 3:61534 |