Printable factfile
Gene Information
Names
HUGO name: CSF3R
Alias(es):
- GCSFR
- Colony stimulating factor 3 receptor (granulocyte)
- Granulocyte colony stimulating factor receptor precursor
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Receptor for granulocyte colony-stimulating factor (G-CSF). In addition it may function in some adhesion or recognition events at the cell surface.
Subunit:
Dimer
Subcellular location:
Type I membrane protein. The GCSFR-2 form, which lacks the transmembrane domain, may represent a soluble form of the receptor.
Structures (PDB)
| 1AZ7 | . |
Domains
Extracellular domain: 25-627
Cytoplasmic domain: 651-836
Ig-like c2-type domain domain: 25-117
Fibronectin type-III 1 domain: 121-227
Fibronectin type-III 2 domain: 228-332
Fibronectin type-III 3 domain: 333-428
Fibronectin type-III 4 domain: 429-525
Fibronectin type-III 5 domain: 526-621
Other features
Signal peptide: 1-24
Granulocyte colony stimulating factor receptor: 25-836
Disulfide bond: 131-142
Disulfide bond: 248-295
Disulfide bond: 266-309
N-linked (glcnac...) glycosylation site: 51
N-linked (glcnac...) glycosylation site: 93
N-linked (glcnac...) glycosylation site: 128
N-linked (glcnac...) glycosylation site: 134
N-linked (glcnac...) glycosylation site: 389
N-linked (glcnac...) glycosylation site: 474
N-linked (glcnac...) glycosylation site: 579
N-linked (glcnac...) glycosylation site: 610
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| spleen | 19.77 | 5:7229 |
| leukocyte | 15.91 | 5:8982 |
| whole blood | 11.69 | 1:2445 |
| osteoarthritic cartilage | 9.53 | 1:2999 |
| ovary (pool of 3) | 6.53 | 1:4380 |
| aorta | 5.56 | 2:10275 |
| bone marrow stroma | 5.36 | 1:5331 |
| placenta | 5.23 | 17:92983 |
| pool, placenta | 4.85 | 2:11794 |
| prostate, epithelium | 3.07 | 1:9299 |