Printable factfile
Gene Information
Names
HUGO name: ELA2
Alias(es):
- SERP1
- Elastase 2, neutrophil
- Serine protease
- Leukocyte elastase precursor
- Neutrophil elastase
- PMN elastase
- Bone marrow serine protease
- Medullasin
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Medullasin modifies the functions of natural killer cells, monocytes and granulocytes.
Catalytic activity:
Hydrolysis of proteins, including elastin. Preferential cleavage: val-|-xaa > ala-|-xaa.
Structures (PDB)
| 1HNE | Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution. |
| 1PPF | X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor. |
| 1PPG | The refined 2.3 A crystal structure of human leukocyte elastase in a complex with a valine chloromethyl ketone inhibitor. |
| 1B0F | Crystal Structure Of Human Neutrophil Elastase With Mdl 101, 146 |
Domains
Other features
Signal peptide: 1-27
Propeptide: 28-29
Leukocyte elastase: 30-267
Disulfide bond: 55-71
Disulfide bond: 151-208
Disulfide bond: 181-187
Disulfide bond: 198-223
N-linked (glcnac...) glycosylation site: 88
N-linked (glcnac...) glycosylation site: 124
N-linked (glcnac...) glycosylation site: 173
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| whole blood | 50.84 | 6:2445 |
| thymus | 46.14 | 1:449 |
| cervix | 1.64 | 2:25325 |
| bone marrow | 1.04 | 1:19854 |
| pool, liver+spleen | 0.34 | 1:61327 |