Printable factfile
Gene Information
Names
HUGO name: C2
Alias(es):
- Complement component 2
- Complement C2 precursor(C3/C5 convertase)
Localization
Reference sequences
- DNA: AF019413 (EMBL)
- cDNA: X04481 (EMBL)
- Protein: P06681 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor 4b to generate the C3 or C5 convertase.
Catalytic activity:
Cleaves C3 in the alpha-chain to yield C3a and C3b. Cleaves C5 in the alpha-chain to yield C5a and C5b. Both cleavages take place at the C-terminal of an Arginine residue.
Miscellaneous:
C2 is a Major Histocompatibility Complex Class-III protein.
Other features
Other related resourses:
- PIR: C2HU
- InterPro: IPR001314; Chymotrypsin
- InterPro: IPR001254; Ser_protease_Try
- InterPro: IPR000436; Sushi_SCR_CCP
- InterPro: IPR002035; VWF_A
- Pfam: PF00084; sushi
- Pfam: PF00089; trypsin
- Pfam: PF00092; vwa
- SMART: SM00032; CCP
- SMART: SM00020; Tryp_SPc
- SMART: SM00327; VWA
- PROSITE: PS50240; TRYPSIN_DOM
- PROSITE: PS00134; TRYPSIN_HIS
- PROSITE: PS00135; TRYPSIN_SER
- PROSITE: PS50234; VWFA
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| eye, cornea | 30.15 | 2:451 |
| skin, melanocyte | 13.07 | 1:520 |
| blood, white cells | 7.47 | 1:910 |
| sympathetic trunk | 7.45 | 1:913 |
| dorsal root ganglia | 6.66 | 1:1021 |
| hepatocellular carcinoma | 5.73 | 12:14226 |
| lung with fibrosis | 4.60 | 1:1479 |
| uterus, endometrium | 3.80 | 1:1790 |
| uterus, pooled | 2.19 | 5:15533 |
| brain, pooled | 2.15 | 1:3166 |