Printable factfile
Gene Information
Names
HUGO name: C9
Alias(es):
- complement component 9
- Complement component C9 precursor
Localization
Reference sequences
- DNA: C9_DNA (C9base)
- cDNA: X02176 (EMBL)
- Protein: P02748 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
C9 is the final component of the complement system to be added in the assembly of the membrane attack complex. It is able to enter lipid bilayers, forming transmembrane channels.
Post-translational modification:
Thrombin cleaves factor C9 to produce C9a and C9b.
Other features
Other related resourses:
- PIR: C9HU
- InterPro: IPR006210; EGF-like
- InterPro: IPR002172; LDL_recept_A
- InterPro: IPR001862; MAC_perforin
- InterPro: IPR000884; TSP1
- Pfam: PF00057; ldl_recept_a
- Pfam: PF00090; tsp_1
- Pfam: PF01823; MACPF
- SMART: SM00192; LDLa
- SMART: SM00457; MACPF
- SMART: SM00209; TSP1
- PROSITE: PS00022; EGF_1
- PROSITE: PS01186; EGF_2
- PROSITE: PS01209; LDLRA_1
- PROSITE: PS50068; LDLRA_2
- PROSITE: PS00279; MAC_PERFORIN
- PROSITE: PS50092; TSP1
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| liver | 34.57 | 34:26031 |
| corresponding non cancerous liver tissue | 26.64 | 14:13909 |
| hepatocellular carcinoma | 22.33 | 12:14226 |
| placenta human 8 week | 13.12 | 2:4035 |
| muscle (skeletal) | 2.77 | 1:9571 |
| pool, lung+testis+b-cell | 0.48 | 1:55714 |
| brain | 0.10 | 1:274929 |