ImmunoDeficiency Resource (IDR)

Names

HUGO name: BF

Alias(es):

Localization

Reference sequences

Chromosomal location

Maps

Variations / Mutations

Other gene-based resources

Description

Protein function:

Factor B which is part of the alternate pathway of the complement system is cleaved by Factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B lymphocytes.

Catalytic activity:

Cleaves C3 in the alpha-chain to yield C3a and C3b. Cleaves C5 in the alpha-chain to yield C5a and C5b. Both cleavages take place at the C-terminal of an Arginine residue.

Subunit:

Monomer

Miscellaneous:

Factor B is a Major Histocompatibility Complex Class-III protein.

Polymorphism:

Two major variants, F and S, and 2 minor variants, as well as at least 14 very rare variants, have been identified.

Other features

Other related resourses:

Expression pattern for human