Printable factfile
Gene Information
Names
HUGO name: SERPING1
Alias(es):
- C1-INH
- C1IN
- C1NH
- complement component 1 inhibitor (angioedema, hereditary)
- Plasma protease C1 inhibitor precursor (C1 Inh) (C1Inh)
Localization
Reference sequences
- DNA: AF435921 (GenBank)
- cDNA: NM_000062 (GenBank)
- Protein: P05155 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins.
Subcellular location:
Secreted
Post-translational modification:
Highly glycosylated (49%).
Polymorphism:
There are two alleles.
Other features
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| adipose, white adipose | 7.78 | 1:268 |
| nose, olfactory epithelium | 5.59 | 3:1119 |
| dorsal root ganglia | 5.57 | 4:1496 |
| human eye anterior segment | 5.26 | 5:1981 |
| testis, epididymus | 4.41 | 2:945 |
| adipose, white adipose tissue | 4.21 | 2:990 |
| uterus, endometrium | 3.48 | 3:1796 |
| brain, miningioma | 2.94 | 1:709 |
| pheochromocytoma | 2.66 | 2:1569 |
| prostate, broad spectrum prostate tumors | 2.54 | 1:821 |