ImmunoDeficiency Resource (IDR)

Names

HUGO name: CASP10

Alias(es):

Localization

Reference sequences

Chromosomal location

Maps

Markers

Variations / Mutations

• CASP10base; Mutation registry for autoimmune lymphoproliferative syndrome type II, (ALPS2)

Other gene-based resources

Description

Protein function:

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both FAS- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-Amc and Asp-Glu-Val-Asp-|-Amc.

Subunit:

Heterodimer of a 23/17 kDa (p23/17) depending on the splicing events and a 12 kDa (p12) subunit.

Post-translational modification:

Cleavage by granzyme B and autocatalytic activity generate the two active subunits.

Tissue specificity:

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

Similarity:

Belongs to peptidase family C14.

Structures (PDB)

Domains

DED 1 domain: 19-97

DED 2 domain: 114-187

Other features

Propeptide: 1-219

Caspase-10 subunit p23/17: 220-415

Caspase-10 subunit p12: 416-521

Other related resourses:

Expression pattern for human

Animal models

Mouse