CD3delta deficiency

CD3delta deficiency is characterized by the absence of T cells but normal numbers of B cells. CD3D is essential for T cell development.

Alternative names

SCID with CD3D chain-deficiency, CD3 complex components

Classification

  • Combined B and T cell immunodeficiencies
    • T-B+ SCID

Inheritance

Autosomal recessive

OMIM

#600802 Severe combined Immunodeficiency, autosomal recessive, T-negative/B-positive type

*186790 CD3 antigen, delta subunit; CD3D

Cross references

Phenotypically related immunodeficiencies

IDR factfile for CD3ε deficiency

IDR factfile for CD3γ deficiency

Incidence

Incidence it is not known until now.