CD3delta deficiency

Gene Information

Names

HUGO name: CD3D

Alias(es):

  • CD3-DELTA
  • T3D
  • CD3D antigen, delta polypeptide (TiT3 complex)
  • T-cell surface glycoprotein CD3 delta chain precursor

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

The CD3 complex mediates signal transduction

Subunit:

The TCR/CD3 complex of T lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta

Subcellular location:

Type I membrane protein

Similarity:

Contains 1 ITAM domain

Structures (PDB)

Domains

Extracellular domain: 22-100

    Cytoplasmic domain: 128-171

      ITAM domain: 146-166

        Other features

        Signal peptide: 1-21

          T-cell surface glycoprotein cd3 delta chain: 22-171

            N-linked (glcnac...) glycosylation sites: 38,74

              Other related resourses:

              Expression

              Expression pattern for human

              Tissue Expression (%) Clones
              thymus 37.03 2:2187
              pooled 28.41 4:5702
              normal prostate 10.08 2:8035
              leukocyte 9.16 2:8838
              2 pooled tumors (clear cell type) 6.32 3:19218
              fetal eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid 2.35 1:17221
              lymph 2.07 1:19564
              carcinoid 1.66 2:48801
              pooled human melanocyte, fetal heart, and pregnant uterus 1.25 1:32508
              unclassified 1.20 26:879462
              thymus 37.03 2:2187
              pooled 28.41 4:5702
              normal prostate 10.08 2:8035
              leukocyte 9.16 2:8838
              2 pooled tumors (clear cell type) 6.32 3:19218
              fetal eyes, lens, eye anterior segment, optic nerve, retina, retina foveal and macular, RPE and choroid 2.35 1:17221
              lymph 2.07 1:19564
              carcinoid 1.66 2:48801
              pooled human melanocyte, fetal heart, and pregnant uterus 1.25 1:32508
              unclassified 1.20 26:879462