Crohn's disease

Gene Information

Names

HUGO name: CARD15

Alias(es):

  • ACUG
  • BLAU
  • PSORAS1
  • caspase recruitment domain family, member
  • nucleotide-binding oligomerization domain protein
  • Caspase recruitment domain protein 15

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Induces NF-kappa-B via rick (cardiak, rip2) and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (lps).

Subunit:

Binds to rick by card-card interaction.

Subcellular location:

Cytoplasmic.

Tissue specificity:

Monocytes-specific.

Similarity:

Contains 2 card domains.

Structures (PDB)

Domains

CARD 1 domain: 26-122

    CARD 2 domain: 126-218

      NACHT domain: 293-618

        Other features

        Caspase recruitment domain protein 15, isoform 1: 1-1040

          Caspase recruitment domain protein 15, isoform 2: 28-1040

            ATP nucleotide phosphate-binding region: 299-306

              Other related resourses:

              Expression

              Expression pattern for human

              Tissue Expression (%) Clones
              pooled 63.09 1:5774
              heart 8.01 1:45449
              blood 7.61 1:47876
              muscle 7.45 2:97778
              lung 5.95 4:244782
              kidney 2.75 1:132304
              uterus 2.66 1:136836
              placenta 2.47 1:147272