Printable factfile
Patients with mutation in λ5 have recurrent otitis, hypoglammaglobulinemia and absent B cells. Patients can develop hemophilus meningitis complicated by arthritis.
Diagnosis
Diagnostic recommendations
Additional Information
Therapeutic options
- (Intravenous) immunoglobulins and antibiotic therapy. Oral poliovaccine should not be given because of the risk of paralytic disease.
- Hypogammaglobulinemia, eMedicine
Research programs, clinical trials
- Improved Healthcare for Patients with Primary Antibody Deficiencies through new Strategies Elucidating their Pathophysiology (IMPAD), IMPAD
- European Initiative for Primary Immunodeficiencies
- Immune Regulation in Patients with Common Variable Immunodeficiency and Related Syndromes, ClinicalTrials.gov