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IgG sublass deficiency is clinically significant only if an impaired response to bacteria such as tetanus, diphteria, and pneumococcus occurs. Antitetanus and antidiphteria antibodies (IgG1) should be checked if the titers for total Igs are normal. Presentation, CVID like, is possible at any age. Patients can have recurrent infections, bronchiectasis, asthma, sinusitis, autoimmune disease.
Diagnosis
Additional Information
Diagnostic laboratories
Clinical:
Genetic:
Therapeutic options
- Only symptomatic patients should be treated. Antibiotic therapy in case there are recurrent infections followed by (intravenous) Ig if infections are not controlled.
- Immunoglobulin G deficiency, eMedicine
- Hypogammaglobulinemia, eMedicine
- IgA and IgG subclass deficiencies, eMedicine