Printable factfile
Gene Information
Names
HUGO name: C1R
Alias(es):
- Complement component 1, r subcomponent
- Complement C1r component precursor
Localization
Reference sequences
- DNA: AB083037 (GenBank)
- cDNA: M14058 (EMBL)
- Protein: P00736 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
C1r b chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Catalytic activity:
Activates C1s by proteolytic cleavage so that it can, in turn, activate C2 and C4.
Subunit:
C1 is a calcium-dependent trimolecular complex of C1q, r and s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, a and b, connected by disulfide bonds.
Structures (PDB)
| 1APQ | Structure Of The Egf-Like Module Of Human C1R, NMR, 19 Structures |
Domains
Cub 1 domain: 18-141
Egf-like, calcium-binding domain: 142-190
Cub 2 domain: 193-305
Sushi 1 domain: 308-372
Sushi 2 domain: 375-448
Serine protease domain: 464-705
Other features
Signal peptide: 1-17
Complement c1r heavy chain: 18-463
Complement c1r light chain: 464-705
Other related resourses:
- PIR: C1HURB
- InterPro: IPR000152; Asx_hydroxyl
- InterPro: IPR000859; CUB_domain
- InterPro: IPR001314; Chymotrypsin
- InterPro: IPR006210; EGF-like
- InterPro: IPR001881; EGF_Ca
- InterPro: IPR001254; Ser_protease_Try
- InterPro: IPR000436; Sushi_SCR_CCP
- Pfam: PF00084; sushi
- Pfam: PF00089; trypsin
- Pfam: PF00431; CUB
- SMART: SM00032; CCP
- SMART: SM00042; CUB
- SMART: SM00179; EGF_CA
- SMART: SM00020; Tryp_SPc
- PROSITE: PS00010; ASX_HYDROXYL
- PROSITE: PS01180; CUB
- PROSITE: PS00022; EGF_1
- PROSITE: PS01186; EGF_2
- PROSITE: PS01187; EGF_CA
- PROSITE: PS50240; TRYPSIN_DOM
- PROSITE: PS00134; TRYPSIN_HIS
- PROSITE: PS00135; TRYPSIN_SER
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| lymph node | 17.52 | 1:125 |
| thyroid gland | 9.64 | 5:1136 |
| skin, normal, 4 pooled samples | 5.81 | 1:377 |
| eye, cornea | 4.86 | 1:451 |
| mammary gland | 4.56 | 3:1441 |
| head/neck | 4.20 | 1:522 |
| gall bladder | 3.60 | 4:2435 |
| normal head/neck tissue | 3.39 | 2:1292 |
| subchondral bone | 3.29 | 2:1332 |
| brain, meningioma | 3.09 | 1:709 |