IL-2 receptor α-chain deficiency (CD25 deficiency)

Gene Information

Names

HUGO name: IL2RA

Alias(es):

  • IL2R
  • interleukin 2 receptor, alpha
  • Interleukin-2 receptor alpha chain precursor
  • IL-2 receptor alpha subunit
  • P55
  • TAC antigen
  • CD25 antigen

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Receptor for interleukin-2.

Subunit:

Non covalent dimer of an alpha and a beta chains. Il-2R exist in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta chain), and a low affinity monomer (alpha chain). The high and intermediate affinity forms also associate with a gamma chain.

Subcellular location:

Type I membrane protein.

Structures (PDB)

1ILM IL2RA
1ILN IL2RA

Domains

Extracellular domain: 22-240

    Cytoplasmic domain: 260-272

      Sushi 1 domain: 23-81

        Sushi 2 domain: 124-185

          Other features

          Signal peptide: 1-21

            Interleukin-2 receptor alpha chain: 22-272

              Disulfide bond: 24-67

                Disulfide bond: 51-80

                  Disulfide bond: 125-168

                    Disulfide bond: 152-184

                      Other related resourses:

                      Expression

                      Expression pattern for human

                      Tissue Expression (%) Clones
                      smooth muscle 46.59 1:647
                      blood, white cells 33.12 1:910
                      grade-2-chondrosarcoma 11.42 1:2639
                      adrenal gland 3.47 2:17391
                      leukocyte 3.36 1:8982
                      unclassified 1.16 2:51898
                      lymph 0.47 1:64395
                      brain 0.22 2:274929
                      lung 0.19 1:155782