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CD25 deficiency begins early in life with recurrent infections and dramatic lymphocytes infiltrates in multiple tissues. The patient had a history of increased susceptibility to viral, bacterial and fungal infections. At the age of 6 months he presented cytomegalovirus pneumonitis, persistant oral thrush, and Candida esophagitis. He had also adenovirus gastroenteritis, developed chronic diarrhea, and failed to thrive. From the age of 8 months he presented lymphadenopathy and hepatosplenomegaly. He had repeted episodes of lung disease and by the age of 3 years developed gingivitis, iron deficiency anemia.
Diagnosis
Diagnostic recommendations
Additional Information
Therapeutic options
- Intravenous gamma-globulin (IVIg) should be started early. Treatment of infections with antibacterials, antivirals and antifungals.
- Severe Combined Immunodeficiency, eMedicine
- National Marrow Donor Program