Printable factfile
Gene Information
Names
HUGO name: C6
Alias(es):
- complement component 6
- Complement component C6 precursor
Localization
Reference sequences
- DNA: C6_DNA (C6base)
- cDNA: NM_000065 (GenBank)
- Protein: P13671 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Involved in the formation of the lytic C5b-9m complex.
Subcellular location:
Secreted
Post-translational modification:
All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module.
Polymorphism:
The sequence shown is that of allotype C6a.
Other features
Other related resourses:
- PIR: A34372
- InterPro: IPR003884; FacI_MAC
- InterPro: IPR002172; LDL_recept_A
- InterPro: IPR001862; MAC_perforin
- InterPro: IPR000436; Sushi_SCR_CCP
- InterPro: IPR000884; TSP1
- InterPro: IPR002350; kazal
- Pfam: PF00050; kazal
- Pfam: PF00057; ldl_recept_a
- Pfam: PF00084; sushi
- Pfam: PF00090; tsp_1
- Pfam: PF01823; MACPF
- SMART: SM00032; CCP
- SMART: SM00057; FIMAC
- SMART: SM00280; KAZAL
- SMART: SM00192; LDLa
- SMART: SM00457; MACPF
- SMART: SM00209; TSP1
- PROSITE: PS00022; EGF_1
- PROSITE: PS01186; EGF_2
- PROSITE: PS01209; LDLRA_1
- PROSITE: PS50068; LDLRA_2
- PROSITE: PS00279; MAC_PERFORIN
- PROSITE: PS50092; TSP1
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| corresponding non cancerous liver tissue | 22.65 | 11:13909 |
| hepatocellular carcinoma | 20.13 | 10:14226 |
| gall bladder | 11.76 | 1:2435 |
| liver | 9.90 | 9:26031 |
| human lung epithelial cell lines untreated lps 6hr to lps | 9.12 | 2:6278 |
| pool, liver+spleen | 7.94 | 17:61327 |
| ovary (pool of 3) | 6.54 | 1:4380 |
| pancreas, exocrine | 4.01 | 3:21418 |
| kidney, pooled | 3.87 | 1:7404 |
| germ cell | 1.43 | 1:20077 |