Printable factfile
Gene Information
Names
HUGO name: C7
Alias(es):
- complement component 7
- Complement component C7 precursor
Localization
Reference sequences
- DNA: C7_DNA (C7base)
- cDNA: J03507 (EMBL)
- Protein: P10643 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
C7 is a constituent of the membrane attack complex. C7 binds to C5b forming the C5b-7 complex, where it serves as a membrane anchor.
Subunit:
Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes.
Post-translational modification:
C7 has 28 disulfide bridges.
Other features
Other related resourses:
- PIR: A27340
- InterPro: IPR003884; FacI_MAC
- InterPro: IPR002172; LDL_recept_A
- InterPro: IPR001862; MAC_perforin
- InterPro: IPR000436; Sushi_SCR_CCP
- InterPro: IPR000884; TSP1
- Pfam: PF00057; ldl_recept_a
- Pfam: PF00084; sushi
- Pfam: PF00090; tsp_1
- Pfam: PF01823; MACPF
- SMART: SM00032; CCP
- SMART: SM00057; FIMAC
- SMART: SM00192; LDLa
- SMART: SM00457; MACPF
- SMART: SM00209; TSP1
- PROSITE: PS00022; EGF_1
- PROSITE: PS01186; EGF_2
- PROSITE: PS01209; LDLRA_1
- PROSITE: PS50068; LDLRA_2
- PROSITE: PS00279; MAC_PERFORIN
- PROSITE: PS50092; TSP1
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| esophageal squamous cell carcinoma | 96.12 | 1:5 |
| ovary, tumor tissue | 0.85 | 2:1125 |
| adrenal cortico adenoma for cushing's syndrome | 0.46 | 1:1050 |
| thyroid gland | 0.42 | 1:1136 |
| normal head/neck tissue | 0.37 | 1:1292 |
| adrenal gland | 0.28 | 10:17391 |
| ear, cochlea | 0.16 | 3:9125 |
| genitourinary tract | 0.13 | 1:3813 |
| prostate, epithelium | 0.10 | 2:9299 |
| kidney | 0.09 | 23:117548 |