Printable factfile
Gene Information
Names
HUGO name: CFI
Alias(es):
- C3b inactivator
- I factor complement
- complement component I
- Complement factor I precursor
- C3B/C4B inactivator
Localization
Reference sequences
- DNA: IF_DNA (IDRefSeq)
- cDNA: J02770 (EMBL)
- Protein: P05156 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and Factor H respectively.
Catalytic activity:
Inactivates complement subcomponents C3b, IC3b and C4b by proteolytic cleavage.
Subunit:
Heterodimer of a light and heavy chains linked by disulfide bonds.
Subcellular location:
Extracellular.
Other features
Other related resourses:
- PIR: A29154
- InterPro: IPR001314; Chymotrypsin
- InterPro: IPR003884; FacI_MAC
- InterPro: IPR002172; LDL_recept_A
- InterPro: IPR001254; Ser_protease_Try
- InterPro: IPR001190; Srcr_receptor
- Pfam: PF00057; ldl_recept_a
- Pfam: PF00089; trypsin
- Pfam: PF00530; SRCR
- SMART: SM00057; FIMAC
- SMART: SM00192; LDLa
- SMART: SM00202; SR
- SMART: SM00020; Tryp_SPc
- PROSITE: PS01209; LDLRA_1
- PROSITE: PS50068; LDLRA_2
- PROSITE: PS00420; SRCR_1
- PROSITE: PS50287; SRCR_2
- PROSITE: PS50240; TRYPSIN_DOM
- PROSITE: PS00134; TRYPSIN_HIS
- PROSITE: PS00135; TRYPSIN_SER
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| ovary, tumor tissue | 13.63 | 1:1125 |
| thyroid gland | 13.50 | 1:1136 |
| muscle, leg skeletal muscle | 8.98 | 1:1708 |
| liver | 7.66 | 13:26031 |
| T cells from T cell leukemia | 6.40 | 1:2397 |
| uterus, pooled | 4.94 | 5:15533 |
| pancreas, islet | 4.23 | 1:3625 |
| kidney, pooled | 4.14 | 2:7404 |
| B cells germinal | 4.07 | 2:7537 |
| genitourinary tract | 4.02 | 1:3813 |